3. Complement and Diseases
نویسندگان
چکیده
منابع مشابه
Complement and glomerular diseases.
The complement pathway is a central part of the innate immune system and also modulates adaptive immunity. It is implicated in the pathogenesis of glomerular disease by a number of clinical findings. These include the presence of complement components in renal biopsy samples, decreases in circulating levels indicating consumption, the presence of autoantibodies to complement proteins and the as...
متن کاملComplement-Mediated Glomerular Diseases: A Tale of 3 Pathways
A renewed interest in the role of complement in the pathogenesis of glomerular diseases has improved our understanding of their basic, underlying physiology. All 3 complement pathways-classical, lectin, and alternative-have been implicated in glomerular lesions both rare (e.g., dense deposit disease) and common (e.g., IgA nephropathy). Here we review the basic function of these pathways and hig...
متن کاملComplement: Deficiency Diseases
Individuals with genetically determined complement deficiencies have a variety of clinical presentations. Most patients present with an increased susceptibility to infection, otherswith a variety of rheumatic diseases, still others with angio-oedema, and in rare instances, patients may even be asymptomatic. The elucidation of the pathophysiological basis for the different clinical presentations...
متن کاملComplement activation, regulation, and molecular basis for complement-related diseases.
The complement system is an essential element of the innate immune response that becomes activated upon recognition of molecular patterns associated with microorganisms, abnormal host cells, and modified molecules in the extracellular environment. The resulting proteolytic cascade tags the complement activator for elimination and elicits a pro-inflammatory response leading to recruitment and ac...
متن کاملComplement in human diseases: Lessons from complement deficiencies.
Complement deficient cases reported in the second half of the last century have been of great help in defining the role of complement in host defence. Surveys of the deficient individuals have been instrumental in the recognition of the clinical consequences of the deficiencies. This review focuses on the analysis of the diseases associated with the deficiencies of the various components and re...
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ژورنال
عنوان ژورنال: Japanese Journal of Medicine
سال: 1989
ISSN: 0021-5120,1881-123X
DOI: 10.2169/internalmedicine1962.28.117